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Article

P212A Mutant of Dihydrodaidzein Reductase Enhances (S)-Equol Production and Enantioselectivity in a Recombinant Escherichia coli Whole-Cell Reaction System.

Applied and environmental microbiology - 22 Jan 2016

Lee Pyung-Gang, Kim Joonwon, Kim Eun-Jung, Jung EunOk, Pandey Bishnu Prasad, Kim Byung-Gee

Abstract excerpt

(S)-Equol, a gut bacterial isoflavone derivative, has drawn great attention because of its potent use for relieving female postmenopausal symptoms and preventing prostate cancer. Previous studies have reported on the dietary isoflavone metabolism of several human gut bacteria and the involved enzymes for conversion of daidzein to (S)-equol. However, the anaerobic growth conditions required by the gut bacteria and...

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Identifiers

PMID: 26801575
DOI: 10.1128/AEM.03584-15
PMCID: PMC4807523

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P212A Mutant of Dihydrodaidzein Reductase Enhances (S)-Equol Production and Enantioselectivity in a Recombinant Escherichia coli Whole-Cell Reaction System.PMID 26801575Read ↗

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