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Article

Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells.

Cell biology and toxicology - 26 Feb 2026

Fourgeaud Mathilde, Auwercx Julie, Lalot Alexis, Noé Laure, Duchêche Belinda, Verdin Anthony, Agrane Sara, Hague Frédéric, Guénin Stéphanie, Jaber Nour, Dupont-Deshorgue Aurélie, Gutierrez Laurent, Chatelain Denis, Ledoux Frédéric, Dhennin-Duthille Isabelle, Brassart Bertrand, Brassart-Pasco Sylvie, Jonckheere Nicolas, Gautier Mathieu

Abstract excerpt

Cadmium (Cd) is a metallic pollutant which has been classified as a possible pancreatic carcinogen. Cd uses similar ion channels than divalent cations to accumulate into the cells. These include the Transient Receptor Potential Cation Channel Subfamily M Member 7 (TRPM7) which has been also shown as a biomarker of pancreatic cancer. Pancreatic carcinogenesis is associated with the establishment of a fibrous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41748892
DOI: 10.1007/s10565-026-10169-0
PMCID: PMC13124864

Genes

TRPM7
MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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