Trastuzumab Deruxtecan in Patients From China With Pretreated HER2-Mutant Non-Small Cell Lung Cancer: Final Analysis of the Phase 2, Single-Arm DESTINY-Lung05 Trial.

doi:10.1016/j.cllc.2026.06.003

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Trastuzumab Deruxtecan in Patients From China With Pretreated HER2-Mutant Non-Small Cell Lung Cancer: Final Analysis of the Phase 2, Single-Arm DESTINY-Lung05 Trial.

Clinical lung cancer - 1 Sept 2026

Liu Ying, Li Dairong, Wu Lin, Li Xingya, Fan Yun, Zhang Mingjun, Guo Jun, Yao Yu, Fang Jian, Tang Ke-Jing, Luo Feng, Yu Yan, Min Xuhong, Song Zizheng, Hu Jie, Ma Rui, Yang Huaping, Shu Yongqian, Xu Ruilian, Wang Buhai, Dong Xiaorong, Chen Yunru, Mao Rui, Zhang Victor, Fang Yong

Abstract excerpt

INTRODUCTION: Trastuzumab deruxtecan (T-DXd) was approved in China in October 2024 for previously treated human epidermal growth factor receptor 2 (HER2)-mutant (HER2m) unresectable/metastatic non-small cell lung cancer (NSCLC), based on DESTINY-Lung02 and DESTINY-Lung05 primary results. Here, we report the DESTINY-Lung05 final analysis. METHODS: DESTINY-Lung05 (NCT05246514), an open-label, single-arm,...

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Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Erb-b2 Receptor Tyrosine Kinases

Trastuzumab

Middle Aged

Aged

China

Mutation

Male

Immunoconjugates

Adult

Antibodies, Monoclonal, Humanized

Camptothecin

Source

Open in PubMed

Identifiers

PMID: 42480250
DOI: 10.1016/j.cllc.2026.06.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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