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Article

Real-world sinonasal outcomes in patients with primary diffuse chronic rhinosinusitis treated with mepolizumab across polyp phenotypes.

Frontiers in immunology - 1 Jan 2026

Kumar Nitish, Patel Evani, Marino Michael J, Lal Devyani

Abstract excerpt

Background: Mepolizumab blocks IL-5, targeting eosinophilic type-2 inflammation. Due to existing phenotype driven patient selection, evidence of its effectiveness in primary diffuse CRS and CRS without nasal polyps (CRSsNP) and in real-world populations is limited. Our objective was to evaluate the real-world effectiveness of mepolizumab in patients with primary diffuse CRS, regardless of nasal polyp status, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41716394
DOI: 10.3389/fimmu.2026.1776180
PMCID: PMC12913089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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