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Article

Risk of ovarian cancer in women with a pathogenic or likely pathogenic variant in NBN: a systematic review and meta-analysis.

American journal of obstetrics and gynecology - 1 Aug 2026

Ganesan Subhasheenee, Mansour Lea, Dibden Amanda, Sideris Michail, Malan Antonetta, Oxley Samuel, Kalra Ashwin, Sia Jacqueline, Wei Xia, Deshmukh Priyanka, Mohamed Hamda, Morgan Robert D, Flaum Nicola, Brentnall Adam, Fierheller Caitlin T, Evans D Gareth, Manchanda Ranjit

Abstract excerpt

OBJECTIVE: NBN is a putative ovarian cancer susceptibility gene. The association between a pathogenic variant in NBN and ovarian cancer is not well established. We aimed to estimate the ovarian cancer risk in unselected women with an NBN pathogenic variant. DATA SOURCES: PubMed and Embase searched from inception to January 2026. ELIGIBILITY CRITERIA: Population: Women diagnosed with ovarian cancer undergoing...

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PMID: 41707894
DOI: 10.1016/j.ajog.2026.02.020

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NBN

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