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Article

LDLR and APOB pathogenic variants predict discordant TSH effect on LDL-C.

Atherosclerosis - 1 Apr 2026

Kafol Jan, Sikonja Jaka, Mlinaric Matej, Cugalj Kern Barbara, Pricop-Jeckstadt Mihaela, Drole Torkar Ana, Gorjanc Tevz, Petek Andraž, Lakner Andreja, Kovac Jernej, Battelino Tadej, Groselj Urh

Abstract excerpt

BACKGROUND AND AIMS: Thyroid hormones regulate lipoprotein metabolism-primarily by up-regulating the LDL receptor. Whether TSH relates to LDL-C in hypercholesterolemic children, and whether this depends on familial hypercholesterolemia (FH) status or the underlying defective gene, is uncertain. We evaluated TSH-lipid associations in prepubertal children and tested effect modification by FH status and, within FH,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41707497
DOI: 10.1016/j.atherosclerosis.2026.120672

Genes

FH
LDLR
APOB
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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