Article
Later age of natural menopause among women with the pathogenic CHEK2 c.1100delC variant: a validation study.
Journal of medical genetics - 20 Apr 2026
Schreurs Maartje A C, Hollestelle Antoinette, Adank Muriel A, Louwers Yvonne, van Asperen Christi J, Ausems Margreet G E M, van de Beek Irma, Collee Margriet J, Dommering Charlotte J, Gómez García Encarna B, Wevers Marijke R, Vieveen Emma M, Yigit Refika, Schmidt Marjanka K, Visser Jenny A, Hooning Maartje J
Abstract excerpt
BACKGROUND: The average age of natural menopause (ANM) for European women is 50-52 years. Reproductive risk and lifestyle factors have been found to be associated with ANM. Furthermore, a genome-wide association study found that women with a CHEK2 variant reach ANM 3.49 years later than women without a CHEK2 variant ('non-carriers'). With this study, we aim to validate this association within CHEK2 c.1100delC...
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