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Article

Multimodal brain-gut-sleep phenotypes predict delirium, long-term cognitive decline, and survival after colorectal cancer surgery.

Psychoneuroendocrinology - 1 May 2026

Pan Shengjie, Wang Gang

Abstract excerpt

BACKGROUND: Neuroimmune, circadian, autonomic, and gut-brain processes jointly shape vulnerability to postoperative delirium and long-term cognitive decline, yet their integrated contribution remains unclear. METHODS: In this prospective cohort (n = 300), preoperative assessments included circadian actigraphy, gut microbial diversity and short-chain fatty acids, inflammatory cytokines (IL-6, CRP), nocturnal heart...

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PMID: 41690125
DOI: 10.1016/j.psyneuen.2026.107794

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