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Article

Genome-Derived Classification Signature for Ampullary Adenocarcinoma to Improve Clinical Cancer Care

25 Aug 2021

Abstract excerpt

Abstract Purpose: The clinical behavior of ampullary adenocarcinoma varies widely. Targeted tumor sequencing may better define biologically distinct subtypes to improve diagnosis and management. Experimental Design: The hidden-genome algorithm, a multilevel meta-feature regression model, was trained on a prospectively sequenced cohort of 3,411 patients (1,001 pancreatic adenocarcinoma, 165 distal bile-duct...

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PMID: 34433650
DOI: 10.1158/1078-0432.ccr-21-1906

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