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Article

Influence of the tumor microenvironment on genetic mutations in thyroid carcinoma.

PloS one - 1 Jan 2026

Zhou Lingyan, Xu Shujian, Song Yuwen, Jiang Dongqing, Chen Shihong

Abstract excerpt

In contrast to cancers with high immunotherapy responsiveness, such as lung cancer and melanoma, thyroid carcinoma (THCA) immunotherapy remains investigational. To establish a theoretical foundation for THCA immunotherapy, we investigated the association between genetic mutations and tumor microenvironment (TME) by analyzing RNA-sequencing data and somatic mutation profiles from 571 THCA samples in The Cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41678466
DOI: 10.1371/journal.pone.0341123
PMCID: PMC12900330

Genes

BRAF
NRAS
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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