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Article

The rewiring of a terminal selector regulatory cascade generates convergent neuronal laterality.

PLoS genetics - 1 Feb 2026

Castro Dylan L, Dimov Ivan M, Mackie Marisa, Carstensen Heather R, Barsegyan Mary T, Hong Ray L

Abstract excerpt

Neuronal identity is established and maintained by "terminal-selector" transcription factors, yet how these networks evolve remains unclear. We examined the specification of the chemosensory ASE and thermosensory AFD neurons in the nematode Pristionchus pacificus, a species that expresses the terminal-selector, Ppa-CHE-1, in both sensory neurons. To determine if the ASE neurons exhibit left-right laterality, we...

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Identifiers

PMID: 41671266
DOI: 10.1371/journal.pgen.1011782
PMCID: PMC12919926

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