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Article

Mathematical modelling of biofilm growth on medical implants incorporating nutrient-dependent phenotypic switching.

Mathematical medicine and biology : a journal of the IMA - 17 Mar 2026

Mandal Parna, Mottram Nigel J, McGinty Sean

Abstract excerpt

Biofilm infections on medical implants are difficult to eradicate because insufficient nutrient availability promotes antibiotic-tolerant persister cells that survive treatment and reseed growth. Existing mathematical models usually omit nutrient-dependent phenotypic switching between proliferative and persister states. Without this mechanism, models cannot capture how environmental conditions control the balance...

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PMID: 41664943
DOI: 10.1093/imammb/dqag002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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