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Article

Determinants of hyperinsulinism severity in children with Beckwith-Wiedemann syndrome.

The Journal of clinical endocrinology and metabolism - 17 Jun 2026

George Andrew M, Viswanathan Aravind, Sussman Jonathan H, Hathaway Evan R, Casalnova Abigail, Nesbitt Salima, Boodhansingh Kara E, Stewart Nicole M, McKnight Heather J, Lord Katherine, De León Diva D, Stanley Charles A, Adzick N Scott, Ganguly Arupa, Kalish Jennifer M

Abstract excerpt

CONTEXT: Congenital hyperinsulinism (HI) is a serious clinical feature of Beckwith-Wiedemann syndrome (BWS) causing severe hypoglycemia. The relationship between BWS genotypes and HI severity is not well understood. OBJECTIVE: Investigate the relationship between molecular determinants of patients with BWS and HI with measures of HI severity. METHODS: This retrospective cohort study included 85 children from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41655234
DOI: 10.1210/clinem/dgag053
PMCID: PMC13271782

Genes

CDKN1C
ABCC8
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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