Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β1/TRAF-6 and IL-6/STAT-3 pathways in PSA-PSMA phenotypes of hormone-sensitive and hormone-refractory prostate Cancer.

Clinical immunology (Orlando, Fla.) - 1 Apr 2026

Jemaa Awatef Ben, Azaiez Mouna Ben, Sallami Sataa, Nouira Yassine, Ghazouani Ezzeddine, Oueslati Ridha

Abstract excerpt

This study explored the relationship between systemic cytokines and PSA-PSMA phenotypes in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), including hormonal therapy response. Serum cytokines (IL-6, TNF-α, IL-10, IL-17 A, TGF-β1) and PSA were quantified, while tissue PSA, PSMA, CD34, TRAF-6, and phosphorylated STAT3 (Ser727, Tyr705) were evaluated immunohistochemically. AR and AR-V7 mRNA expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostate-Specific Antigen

Share to Prostatic Hyperplasia

Share to Receptors, Androgen

Share to STAT3 Transcription Factor

Share to TNF Receptor-Associated Factor 6

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 41651273
DOI: 10.1016/j.clim.2026.110679

Genes

AR
CD34
STAT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β1/TRAF-6 and IL-6/STAT-3 pathways in PSA-PSMA phenotypes of hormone-sensitive and hormone-refractory prostate Cancer.PMID 41651273Read ↗

Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate CancerSemantic proximity Read ↗

RNA sequencing and integrative analysis reveal pathways and hub genes associated with TGFβ1 stimulation on prostatic stromal cellsSemantic proximity Read ↗

Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironmentSemantic proximity Read ↗

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.Semantic proximity Read ↗

Ex Vivo Signaling Protein Mapping in T Lymphocytes in the Psoriatic Arthritis Joints.Semantic proximity Read ↗

Lipidosterolic Extract of Serenoa Repens Modulates the Expression of Inflammation Related-Genes in Benign Prostatic Hyperplasia Epithelial and Stromal CellsSemantic proximity Read ↗

IL-17F facilitates prostate cancer cell malignant phenotypes via activation of the PI3K/AKT signalling pathway.Semantic proximity Read ↗

Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanismSemantic proximity Read ↗

Sex differences in serum proteomic profiles in psoriatic arthritisSemantic proximity Read ↗

Genetic polymorphisms in inflammation pathway genes and prostate cancer risk.Semantic proximity Read ↗

Transforming growth factor β-receptor II protein expression in benign prostatic hyperplasia is associated with prostate volume and inflammation.Semantic proximity Read ↗

STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.