cagA-positive Helicobacter pylori and human NOS2-954G/C polymorphism: A possible association with severe clinical outcomes in Iranian patients.

doi:10.1016/j.meegid.2026.105891

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Article

cagA-positive Helicobacter pylori and human NOS2-954G/C polymorphism: A possible association with severe clinical outcomes in Iranian patients.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2026

Rezaeian Tayebeh, Mohammadzadeh Roghayeh, Akbari Shadi, Namdar Ali Beheshti, Baghaee Bita, Ahmadi Ayat, Farsiani Hadi

Abstract excerpt

Helicobacter pylori infects more than 50% of the global population. The diversity and severity of clinical outcomes are attributed to the complex interaction among pathogen, host, and environmental factors. This study investigated the association between H. pylori virulence genes (cagA, vacA, and...

Topics

Humans
Helicobacter pylori
Helicobacter Infections
Antigens, Bacterial
Bacterial Proteins
Iran
Female
Male
Nitric Oxide Synthase Type II
Middle Aged
Adult
Genotype
Peptic Ulcer
Aged
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 41638461
DOI: 10.1016/j.meegid.2026.105891

Genes

NOS2
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41638461-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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