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Article

The apolipoprotein gene: a modulating role on brain volume and cognitive function in carriers of the fragile X premutation.

Neurobiology of disease - 1 Mar 2026

Jiraanont Poonnada, Wang Jun Yi, Durbin-Johnson Blythe, Hwang Ye Hyun, Hessl David, Rivera Susan M, Hagerman Randi J, Tassone Flora

Abstract excerpt

Fragile X-associated tremor/ataxia syndrome (FXTAS), caused by the FMR1 premutation allele, is associated with brain degeneration, yet the mechanisms behind this neurodegeneration still need to be elucidated. Apoε polymorphism has been widely implicated in brain aging in cognitively healthy individuals and brain deterioration in Alzheimer's disease. This study aimed to examine the interaction of Apoε genotypes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41638369
DOI: 10.1016/j.nbd.2026.107292
PMCID: PMC13325199

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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