Article
Genetic evidence for POR-mediated ferroptosis in lung cancer prevention: a causal role of granulocyte modulation.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Jul 2026
Qian Lujie, Wu Linyu, Lou Xinjing, Kong Ning, Wu Ting, Hu Hongjie, Xu Maosheng, Gao Chen
Abstract excerpt
BACKGROUND: Cytochrome P450 oxidoreductase (POR) plays a vital role in ferroptosis within lung cancer. A potential link exists between ferroptosis-related genes and immune cell activity. This research aimed to confirm whether POR influences lung cancer by modulating immune cells. METHODS: Genetic variants of the POR gene were identified from lung tissue expression quantitative trait loci (eQTL) data using single...
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