Article
First Identification of BoLA-DRB3 Alleles Associated with Differential Susceptibility to Bovine Leukemia Virus Infection and Proviral Load in Chinese Holstein Cattle.
Pathogens (Basel, Switzerland) - 25 Dec 2025
Wang Jingyuan, Matsuura Ryosuke, Watanuki Sonoko, Bao Aronggaowa, Fukushi Noriko, Matsumoto Yasunobu, Dong Lin, Guo Guangjun, Yao Chunyang, Wang Changjiang, Wei Feng, Liu Jishan, Wang Xuebo, Tian Fengrong, Wang Jinliang, Aida Yoko
Abstract excerpt
Bovine leukemia virus (BLV), the most prevalent neoplastic disease of cattle worldwide, is the causative agent of enzootic bovine leukosis. Polymorphisms in the bovine leukocyte antigen (BoLA)-DRB3 gene can influence host immune responses to pathogens, including BLV. However, the associations between specific BoLA-DRB3 alleles, BLV proviral load (PVL), a useful index for estimating disease progression and...
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