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Article

Residue-Specific Dock-Loosen-Unfold Mechanism of GB1 on Nanoparticle Surfaces Revealed by Kinetic and Φ-Value Analysis.

Biomolecules - 8 Jan 2026

Liu Tingting, Bian Yunqiang, Wang Siyu, Li Yang, Cao Yi, Jiao Yonghua, Pan Hai

Abstract excerpt

Nanoparticles interact dynamically with proteins, often leading to adsorption-induced conformational changes that alter protein function and contribute to corona formation. Here we investigated the adsorption and unfolding of a model protein GB1 on latex nanoparticle surfaces using a combination of mutational analysis, equilibrium binding assays, stopped-flow kinetics and Φ-value interpretation. Seven...

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Identifiers

PMID: 41594654
DOI: 10.3390/biom16010114
PMCID: PMC12839133

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