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Article

Oligoprotein type I interferon signatures, but not TREX1 variants, increase risk of systemic lupus erythematosus in UK Biobank.

Nature communications - 27 Jan 2026

Rioux Bastien, McGlasson Sarah, Forbes Deborah, Reid Katy R, Klingseisen Anna, Berry Joe, Dhaun Neeraj, Ng Wan Fai, Whiteley William, Hunt David P J

Abstract excerpt

The 3' - 5' DNA exonuclease, TREX1, is a negative regulator of the type I interferon response, while TREX1 variants are considered to confer risk for non-monogenic systemic lupus erythematosus (SLE). Here we analyse TREX1 sequences in 469,229 UK Biobank participants together with multi-omics data from the UK Biobank Pharma Proteomics Project to reappraise the contribution of reported TREX1 risk variants in SLE....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41593088
DOI: 10.1038/s41467-025-67832-z
PMCID: PMC12852752

Genes

TREX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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