Article
Oxytocin Receptor Polymorphism rs53576 Is Linked to Habitual Alcohol and Sucrose Intake, as well as Liver Steatosis, in a General Japanese Population Cohort.
The Journal of nutrition - 1 Mar 2026
Goto Hisanori, Yamamoto Yasuhiko, Tsujiguchi Hiromasa, Sato Takehiro, Takeshita Yumie, Nakano Yujiro, Kannon Takayuki, Hosomichi Kazuyoshi, Hara Akinori, Yokoyama Shigeru, Tajima Atsushi, Nakamura Hiroyuki, Takamura Toshinari
Abstract excerpt
BACKGROUND: Oxytocin (OXT) signaling through the oxytocin receptor (OXTR) produces stress-relieving effects and modulates alcohol reward and sucrose preference in animal models. These findings suggest the therapeutic potential of OXT for alcohol use disorder (AUD) and liver steatosis. However, human genetic evidence linking OXT signaling to these cravings remains scarce. OBJECTIVES: This study examined the...
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