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Article

Metformin treatment and reduction of gastrointestinal cancer risk: A 2-sample Mendelian randomization study.

Medicine - 23 Jan 2026

Huang Dongcun, Zhang Fujun, Huang Tao

Abstract excerpt

This study aimed to examine the causal relationship between metformin treatment and the prevention of various cancer types through a 2-sample Mendelian randomization (MR) analysis. Utilizing genome-wide association study summary data, a 2-sample MR approach was employed to assess the association between metformin treatment and multiple cancer types. The analysis further investigated the causal effects of specific...

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Gastrointestinal Neoplasms
Genome-Wide Association Study
Hypoglycemic Agents
Mendelian Randomization Analysis
Metformin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 41578601
DOI: 10.1097/MD.0000000000047322
PMCID: PMC12851687

Genes

GDF15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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