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Article

Exploring the association between sweet liking and treatment response to naltrexone in patients with alcohol use disorder.

The international journal of neuropsychopharmacology - 2 Feb 2026

Chang Min-Chiao, Chen Chun-Hsin, Meng Shih-Chun, Shu Shu-Hao, Chang Hu-Ming, Huang Ming-Chyi

Abstract excerpt

BACKGROUND: Response to naltrexone varies among individuals with alcohol use disorder (AUD). Studies in Western populations have linked the sweet-liking (SL) phenotype, reflecting an individual's hedonic response to sweet taste, to improved outcomes with naltrexone. However, cultural and ethnic variations in SL raise questions about the generalizability of this association. This exploratory investigation examined...

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Identifiers

PMID: 41575192
DOI: 10.1093/ijnp/pyag004
PMCID: PMC12931563

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