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Article

Tyrer-Cuzick Lifetime Risk Is Not Associated With Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma.

The breast journal - 1 Jan 2026

Rao Divya, Wernecke Chloe, Baron Lisa, Cai Steven, Beitsch Peter, Patel Rakesh, Whitworth Pat, Rosen Barry, Tran Nhan Nguyen, Hughes Kevin, Baron Paul L

Abstract excerpt

Background: The Tyrer-Cuzick (TC) or IBIS risk calculator is a widely used tool to estimate the probability of developing breast cancer. The latest version incorporates various factors to assess the risk of breast cancer, including family history, personal history, breast density, and past medical history. The TC is commonly used to guide patients toward further diagnostic imaging, genetic testing,...

Topics

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Aged
BRCA1 Protein
Breast Neoplasms
BARD1 gene
Genes, BRCA1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genetic Testing

Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 41568159
DOI: 10.1155/tbj/8670441
PMCID: PMC12816757

Genes

BRCA1
BRCA2
BARD1
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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