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Article

A KEL gene encoding serine at position 193 of the Kell glycoprotein results in expression of KEL1 antigen.

Transfusion - 1 Nov 2006

Poole Joyce, Warke Nicole, Hustinx Hein, Taleghani Behrouz Mansouri, Martin Peter, Finning Kirstin, Crew Vanja Karamatic, Green Carole, Bromilow Imelda, Daniels Geoff

Abstract excerpt

BACKGROUND: The KEL2/KEL1 (k/K) blood group polymorphism represents 578C>T in the KEL gene and Thr193Met in the Kell glycoprotein. Anti-KEL1 can cause severe hemolytic disease of the fetus and newborn. Molecular genotyping for KEL*1 is routinely used for assessing whether a fetus is at risk. Red blood cells (RBCs) from a KEL:1 blood donor (D1) were found to have abnormal KEL1 expression during evaluation of...

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Source

Identifiers

PMID: 17076841
DOI: 10.1111/j.1537-2995.2006.00993.x

Genes

KEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A KEL gene encoding serine at position 193 of the Kell glycoprotein results in expression of KEL1 antigen.PMID 17076841Read ↗

Another example of a KEL1 variant red cell phenotype due to a threonine to serine change at position 193 of Kell glycoprotein.Semantic proximity Read ↗

Molecular basis of the Kell (K1) phenotype.Semantic proximity Read ↗

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A novel KEL*1,3 allele with weak Kell antigen expression confirming the cis-modifier effect of KEL3.Semantic proximity Read ↗

Novel alleles at the Kell blood group locus that lead to Kell variant phenotype in the Dutch population.Semantic proximity Read ↗

Genotyping of KEL1 and KEL2 of the human Kell blood group system by the polymerase chain reaction with sequence-specific primers.Semantic proximity Read ↗

Identification of novel silent KEL alleles causing KEL:-5 (Ko) phenotype or discordance between KEL:1,-2 phenotype/KEL*01/02 genotype.Semantic proximity Read ↗

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Three uncommon KEL alleles in one family with unusual Kell phenotypes explain a 35-year old conundrum.Semantic proximity Read ↗

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