Resistance to sulbactam/durlobactam in carbapenem-resistant Acinetobacter baumannii in treatment-naive setting: In vitro data and genomic insights from Italian bloodstream isolates.

Abstract excerpt

OBJECTIVE: This study evaluated the in vitro activity of sulbactam/durlobactam and comparators against carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream isolates from Italy and investigated genomic mechanisms underlying resistance. METHODS: A total of 110 consecutive CRAB isolates (2021-2023) were tested for susceptibility to sulbactam/durlobactam, cefiderocol, colistin, and comparators....

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