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Article

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.

Bone - 1 Dec 2013

van der Eerden B C J, Oei L, Roschger P, Fratzl-Zelman N, Hoenderop J G J, van Schoor N M, Pettersson-Kymmer U, Schreuders-Koedam M, Uitterlinden A G, Hofman A, Suzuki M, Klaushofer K, Ohlsson C, Lips P J A, Rivadeneira F, Bindels R J M, van Leeuwen J P T M

Abstract excerpt

We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and histomorphometrical analyses demonstrated reduced osteoclast activity and numbers in male Trpv4(-/-) mice, which was conf...

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Source

Identifiers

PMID: 24084385
DOI: 10.1016/j.bone.2013.09.017

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24084385-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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