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Article

Fatal Mycobacterium tilburgii disseminated infection in a patient with cryptic interleukin-12Rβ1 deficiency: A case report.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Mar 2026

Eon Sophie, Giot Jean Baptiste, Frippiat Frederic, Mathys Vanessa, Radermacher Jean, Paquot Constance, Schils Raphael

Abstract excerpt

We report the case of an immunocompromised patient with previously unrecognized Mendelian susceptibility to mycobacterial disease due to interleukin-12Rβ1 deficit, who developed fatal disseminated Mycobacterium tilburgii infection. Mycobacterial invasion caused severe neurologic complications, including refractory status epilepticus, leading to death, despite therapies, including surgical interventions.

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Identifiers

PMID: 41519375
DOI: 10.1016/j.ijid.2026.108386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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