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Omics analyses decoding mechanisms underlying the self-flocculating phenotype of yeast cells and stress tolerance for robust production.

Metabolic engineering - 1 Apr 2026

Zhang Xue, Dai Yang, Zhao Xin-Qing, Liu Chen-Guang, Wang Zhuo, Bai Feng-Wu

Abstract excerpt

A unique self-flocculating yeast strain SPSC01 was developed through protoplast fusion for fuel ethanol production with high product titers. In this study, we conducted comparative multi-omics analyses on SPSC01 to elucidate mechanisms underlying its self-flocculating phenotype and associated stress tolerance, the most desirable merit for robust production in industry. Leveraging two cutting-edge third-generation...

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PMID: 41513117
DOI: 10.1016/j.ymben.2026.01.003

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