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Article

Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses.

Nature communications - 8 Jan 2026

Lyu Yilin, Shi Yi, Song Kunfeng, Zhou Jungang, Chen Hao, Li Xueying C, Yu Yao, Lu Hong

Abstract excerpt

Interspecific genetic exchanges caused by natural hybridization or horizontal gene transfer can lead to enhanced phenotypes, which are often of interest for industrial applications and evolutionary research. However, transferring genetic materials between distantly related species, such as intergeneric yeasts, presents technical challenges. In this study, we establish a method to transfer individual chromosomes...

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Identifiers

PMID: 41507170
DOI: 10.1038/s41467-025-68164-8
PMCID: PMC12881598

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