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Myelitis-Predominant Aggressive Phenotype: Unveiling Unique Patterns of Late-Onset Neuromyelitis Optica Spectrum Disorders.

Annals of neurology - 1 May 2026

Pu Ya-Lan, Feng Jin-Zhou, Meng Hua-Xing, Xiao Hai-Bing, Li Xiao-Ling, Zhen Jin, Lu Wen-Ying, Xi Xu-Ming, Wu Ti, Yuan Bao-Shi, Fan Mo-Li, Zhang Chao, Tian De-Cai, Meng Xia, Shi Fu-Dong, Song Tian

Abstract excerpt

OBJECTIVE: The objective of this study was to compare clinical features and prognosis of late-onset neuromyelitis optica spectrum disorder (LO-NMOSD, onset age ≥60 years) with adult-onset NMOSD (AO-NMOSD, onset age 18-59 years), and to provide insights for individualized management in elderly patients. METHODS: Data from 748 patients with NMOSD (diagnosed according to the 2015 International Panel for NMO...

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PMID: 41510886
DOI: 10.1002/ana.78146
PMCID: PMC13092785

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