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Article

Pathology and viral evolutionary dynamics in a hamster model of persistent SARS-CoV-2 infection.

Communications biology - 8 Jan 2026

Wei Wanting, Kuroda Makoto, Liu Yanan, Iida Shun, Kandel Sangam, Machovech Heather, Hirata Yuichiro, Suzuki Tadaki, Koelle Katia, Wang Zhongde, Friedrich Thomas C, Kawaoka Yoshihiro, Halfmann Peter J

Abstract excerpt

SARS-CoV-2 infection typically resolves within weeks, but rare cases of prolonged replication-sometimes exceeding a year-have been documented, particularly in immunocompromised individuals. These persistent infections pose health risks and may give rise to highly divergent variants, yet the underlying biology remains poorly understood. Here, we describe a model of SARS-CoV-2 persistence using transgenic Syrian...

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Animals, Genetically Modified
COVID-19
Cricetinae
Disease Models, Animal
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

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Identifiers

PMID: 41501552
DOI: 10.1038/s42003-025-09473-y
PMCID: PMC12881346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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