Functional impact of IL-36γ rs28947206/rs28947207 and IL-17 a rs2275913 polymorphisms in polycystic ovary syndrome: Novel insights from the Iraqi population.

Abstract excerpt

Polycystic ovary syndrome (PCOS) affects 4-21 % of reproductive-aged women, with elevated prevalence in Iraq. It involves chronic inflammation and dysregulated pro-inflammatory cytokines. This study investigates serum IL-17 A levels and its rs2275913 polymorphism, alongside the novel relevance of IL-36γ and its rs28947206/rs28947207 variants in PCOS pathogenesis. A total of 178 women underwent clinical, hormonal,...