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Article

TP53 Genotype-Dependent Cellular Responses to DVDMS-Sonodynamic Therapy in Oral Squamous Cell Carcinoma.

Ultrasound in medicine & biology - 1 Mar 2026

Dong Guo-Gang, Pan Pin-Xiu, Zhang Feng-Ting, Zhang Xi-Mei, Yang Fu-Yu, Jia Li-Min, Zhang Wei-Han, Lv Yan-Hong

Abstract excerpt

OBJECTIVE: This study aimed to assess the inhibitory effects and underlying mechanisms of sonodynamic therapy (SDT) mediated by the novel sonosensitizer sinoporphyrin sodium (DVDMS) in oral squamous cell carcinoma (OSCC) cells exhibiting distinct TP53 genotypes. METHODS: Cytotoxicity, intracellular uptake and localization of DVDMS, reactive oxygen species (ROS) levels, apoptosis and autophagy were assessed in two...

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Identifiers

PMID: 41456973
DOI: 10.1016/j.ultrasmedbio.2025.11.011

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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