Article
Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer.
Scientific reports - 12 Apr 2023
Hatcher Charlie, Richenberg George, Waterson Samuel, Nguyen Long H, Joshi Amit D, Carreras-Torres Robert, Moreno Victor, Chan Andrew T, Gunter Marc, Lin Yi, Qu Conghui, Song Mingyang, Casey Graham, Figueiredo Jane C, Gruber Stephen B, Hampe Jochen, Hampel Heather, Jenkins Mark A, Keku Temitope O, Peters Ulrike, Tangen Catherine M, Wu Anna H, Hughes David A, Rühlemann Malte C, Raes Jeroen, Timpson Nicholas J, Wade Kaitlin H
Abstract excerpt
The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on the topic are unable to discern correlation from causation. We apply two-sample Mendelian randomization (MR) to estimate the causal relationship between the gut microbiome and CRC. We used summary-level data from independent genome-wide association studies to estimate the causal effect of 14 microbial traits (n = 3890...
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