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Genetic susceptibility, walking activity and the risk of incident gout.

Rheumatology (Oxford, England) - 4 Feb 2026

Wu Ziying, Hu Ying, Wang Yilun, Zhang Yuqing, He Hongyi, Zeng Chao, Lei Guanghua, Wei Jie

Abstract excerpt

OBJECTIVES: Genetic predisposition increases the risk of gout, while walking activity may reduce it. We evaluated whether genetic predisposition modifies the association between walking activity and gout risk. METHODS: We included gout-free participants aged 40-70 years from the UK Biobank. Polygenic risk scores (PRS) were calculated using gout-associated single nucleotide polymorphisms, and participants were...

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PMID: 41452761
DOI: 10.1093/rheumatology/keaf690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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