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Article

Diffuse Large B-Cell Lymphoma Transdifferentiating Into Histiocytic Sarcoma: Case Report + Systematic Review.

Journal of cutaneous pathology - 1 Apr 2026

Mansfield Patricia K, Mehrmal Sino, Hurley M Yadira, Aria Alexander B, Goyal Sagun, Burkemper Nicole M, Heinecke Gillian, Smith Kristin, Kreisel Friederike, Smith Emily

Abstract excerpt

A 68-year-old man with a history of diffuse large B-cell lymphoma (DLBCL) with cutaneous involvement presented with a new, rapidly growing, exophytic, bleeding tumor. Histopathologic and immunophenotypic characterization was consistent with a diagnosis of histiocytic sarcoma (HS). A subsequent lymph node biopsy also yielded a diagnosis of HS. Genetic analysis of this patient's original DLBCL bone marrow specimen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41451843
DOI: 10.1111/cup.70051

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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