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Multiplexed Electrochemical Sensing of Single-Nucleotide Polymorphic Microribonucleic Acids in Liver Cancer.

Analytical chemistry - 13 Jan 2026

Sasa Gabriel B K, Chen Chong, He Baixun, Zhang Wenxin, Borlay Allen J, Tan Cherie S, Ming Dong

Abstract excerpt

Liver cancer remains a highly lethal malignancy, primarily due to the limitations of current biomarkers like α-fetoprotein, which fail to detect many early-stage cases. MicroRNAs (miRNAs) have emerged as promising diagnostic biomarkers, particularly those influenced by single-nucleotide polymorphisms (SNPs). However, conventional electrochemical biosensors for miRNA detection often require complex probe...

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PMID: 41451458
DOI: 10.1021/acs.analchem.5c03442

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