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Article

Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk.

Pediatric blood & cancer - 1 Feb 2026

Tark Ji Yun, Renwick Alexander, Yu Yao, Sabo Aniko, Olshan Andrew F, Plon Sharon E, Huff Chad D, Lupo Philip J

Abstract excerpt

Children with congenital heart disease (CHD) have elevated neuroblastoma (NB) risk, potentially due to shared neural crest origins. We analyzed rare exonic de novo single-nucleotide variants in 702 CHD and 454 NB trios from the Neuroblastoma Epidemiology in North America Study, Gabriella Miller Kids First Program, and a published cohort. Seven genes, including CHD risk genes POGZ and LZTR1 (linked to Noonan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41431348
DOI: 10.1002/1545-5017.70055
PMCID: PMC13449798

Genes

CIC
LZTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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