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Article

De novo damaging variants associated with congenital heart diseases contribute to the connectome.

Scientific reports - 27 Apr 2020

Ji Weizhen, Ferdman Dina, Copel Joshua, Scheinost Dustin, Shabanova Veronika, Brueckner Martina, Khokha Mustafa K, Ment Laura R

Abstract excerpt

Congenital heart disease (CHD) survivors are at risk for neurodevelopmental disability (NDD), and recent studies identify genes associated with both disorders, suggesting that NDD in CHD survivors may be of genetic origin. Genes contributing to neurogenesis, dendritic development and synaptogenesis organize neural elements into networks known as the connectome. We hypothesized that NDD in CHD may be attributable...

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Identifiers

PMID: 32341405
DOI: 10.1038/s41598-020-63928-2
PMCID: PMC7184603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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