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Article

Causal influences of migraine on neuropsychiatric disorders: A 2-sample Mendelian randomization study.

Medicine - 19 Dec 2025

Xu Tiantian, Gao Qinlong, Hu Lingsan, Deng Bing, Ren Qing, Du Genfa, Xi Dan

Abstract excerpt

Our study aims to explore the causal relationship between migraine (with and without aura) and 6 disorders: anxiety, bipolar disorder, epilepsy, major depressive disorder, insomnia, and stroke, using a 2-sample Mendelian randomization. Migraine without aura had a significant causal association with bipolar disorder (odds ratios = 1.075, 95% confidence intervals = [1.005-1.151], P = .037). A complex relationship...

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Identifiers

PMID: 41431096
DOI: 10.1097/MD.0000000000046041
PMCID: PMC12727394

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