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Article

A rare large cell variant of small-cell carcinoma of the ovary, hypercalcemic type in a postmenopausal woman: Case report.

Medicine - 19 Dec 2025

Liu Simeng, Che Shuping, Jin Cuicui, Deng Yuhui, Zhao Deli

Abstract excerpt

RATIONALE: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an extremely rare and aggressive ovarian malignancy associated with SMARCA4 mutation, accounting for less than 0.01% of ovarian tumors. It predominantly affects young females and is characterized by poor prognosis. Here, we report a unique case of SCCOHT with a special pathological classification of large cell variant type in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41431072
DOI: 10.1097/MD.0000000000046423
PMCID: PMC12727351

Genes

SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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A rare large cell variant of small-cell carcinoma of the ovary, hypercalcemic type in a postmenopausal woman: Case report.PMID 41431072Read ↗

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Small Cell Carcinoma of Ovary, Hypercalcemic Type: Cytologic, Histopathologic, and Immunohistochemical Landscapes of a Rare Case.Semantic proximity Read ↗

An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular FindingsSemantic proximity Read ↗

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Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic TypeSemantic proximity Read ↗

Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutationsSemantic proximity Read ↗

Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis.Semantic proximity Read ↗

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4.Semantic proximity Read ↗

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