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Solving Riddles Through Sequencing (SIRIUS): unlocking hematologic diagnoses by whole genome and transcriptome sequencing.

Leukemia - 1 Jan 2026

Truger Marietta, Meggendorfer Manja, Walter Wencke, Hutter Stephan, Alsdorf Winfried, Massenkeil Gero, Martens Uwe M, Kern Wolfgang, Hörst Katharina, Kühn Constanze, Reiter Andreas, Hochhaus Andreas, Haferlach Torsten

Abstract excerpt

In the rapidly evolving field of hematology, the diagnosis of leukemias and lymphomas poses major challenges, despite significant genetic advancements. Although established diagnostic methods comprise a multidisciplinary approach and are considered gold standard, in some cases they fall short in conclusively identifying hematological neoplasms. In this context, the current SIRIUS study (NCT05046444) delves into...

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PMID: 41419605
DOI: 10.1038/s41375-025-02820-2
PMCID: PMC12789012

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