Article
DEOGEN2: prediction and interactive visualization of single amino acid variant deleteriousness in human proteins.
Nucleic acids research - 3 Jul 2017
Raimondi Daniele, Tanyalcin Ibrahim, Ferté Julien, Gazzo Andrea, Orlando Gabriele, Lenaerts Tom, Rooman Marianne, Vranken Wim
Abstract excerpt
High-throughput sequencing methods are generating enormous amounts of genomic data, giving unprecedented insights into human genetic variation and its relation to disease. An individual human genome contains millions of Single Nucleotide Variants: to discriminate the deleterious from the benign ones, a variety of methods have been developed that predict whether a protein-coding variant likely affects the carrier...
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