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Article

Preserved cognitive-functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2025

Lozada-Martinez Ivan David, Castelblanco-Toro Sandra Milena, Guillen-Burgos Hernán F, Salazar-Uribe Juan Carlos, Anaya Juan-Manuel

Abstract excerpt

INTRODUCTION: Research on dementia in centenarians is scarce. This study assesses the 2024 Lancet Commission risk factors for dementia in Colombian centenarians. METHODS: The Clinical Dementia Rating-Sum of Boxes (CDR-SB), Mini-Mental State Examination, and Barthel Index were evaluated in Colombian centenarians. A preserved cognitive-functional phenotype (PCFP), defined by a CDR-SB <2 and a Barthel index ≥60, was...

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PMID: 41400045
DOI: 10.1002/alz.71034
PMCID: PMC12706638

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