Article
A Rapid Assay for Hepatitis C Virus RNA Detection Using Reverse-Transcription Loop-Mediated Isothermal Amplification-Coupled CRISPR-Cas12b-Based Strategy.
The Journal of infectious diseases - 15 May 2026
Chowdhury Avisha, Garcia Bianca Garcia, Zahoor Muhammad Atif, ElMawla Nahla Fadl, Davidson Alan R, Wyatt Haley D M, Maxwell Karen L, Mahassine Ayoub, Gehring Adam, Feld Jordan J
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) diagnosis usually requires detection of antibody followed by HCV RNA. The requirement for 2 tests leads to major drop-offs in the cascade of care. Existing near-care HCV RNA tests have slow turnaround time and are expensive with limited availability. We aim to develop a cost-effective, rapid, and sensitive test for detection of HCV RNA to enhance screening, particularly in...
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