Comprehensive Multiomics Characterization of Perineural Invasion in Cervical Cancer Reveals Diagnostic Markers, Molecular Drivers, and Therapeutic Strategies.

Abstract excerpt

Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is associated with poor prognosis and provides key information for clinical decisions. A better understanding of the molecular mechanisms underlying PNI could lead to improved patient treatment strategies. Here, we generated whole-exome, whole-genome, and RNA sequencing data from tumors and matched normal clinical samples of 45...

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• Exome Sequencing
• F-Box-WD Repeat-Containing Protein 7
• Machine Learning
• Multiomics
• Neoplasm Invasiveness