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Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca 2+ -Activated K + Channels via Epigenetic Alteration at Gene Promoter in Male Offspring

24 Sept 2020

Abstract excerpt

Objective: Antenatal exposure to glucocorticoids increases cardiovascular risks related to vascular dysfunctions in offspring, although underlying mechanisms are still unknown. As an important vascular mediator, high-conductance Ca 2+ -activated K + channels (BK) plays an essential role in determining vascular tone. Long-term effects of antenatal glucocorticoids on BK in offspring are largely unknown. This study...

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PMID: 32967457
DOI: 10.1161/atvbaha.120.314905

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