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Article

The rs34416841 polymorphism in the Alu element of the circSirt1 flanking intron is associated with an increased risk of myocardial infarction.

BMC medical genomics - 6 Dec 2025

Zhou Yu-Lan, Yang Wen-Cong, Liao Zhao-Fu, Zheng Shu-Rou, Qu Yun-Fei, Li Heng, Mo Hai-Liang, Xie Yi-Tuan, Wu Zhu-Guo, Xiong Xing-Dong

Abstract excerpt

BACKGROUND: circSirt1 can ameliorate neointimal hyperplasia and provide protection against atherosclerosis. Single nucleotide polymorphisms (SNPs) in circRNA flanking introns, particularly within Alu elements, may alter back-splicing and influence circRNA formation efficiency. To investigate the association between polymorphisms in the circSirt1 flanking introns and susceptibility to myocardial infarction (MI),...

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PMID: 41353146
DOI: 10.1186/s12920-025-02291-5
PMCID: PMC12797537

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CAD

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