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Article

Integrating clinical features with 11C-methionine PET-MRI radiomics for non-invasive prediction of H3 K27M mutation in brainstem gliomas.

BMC medical imaging - 4 Dec 2025

Zhang Shu, Li Xiaotong, Wang Yanmei, Wu Yuliang, Ai Lin, Zhang Liwei, Zhao Xiaobin

Abstract excerpt

BACKGROUND: Accurate determination of H3 K27M mutation status is critical for prognosis evaluation and treatment planning in brainstem gliomas (BSGs). We developed a clinical-radiomics model integrating 11C-methionine (11C-MET) positron emission tomography (PET), magnetic resonance imaging (MRI), and clinical features for non-invasive, preoperative prediction of H3 K27M mutation status in BSGs. METHODS: This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41339805
DOI: 10.1186/s12880-025-02103-3
PMCID: PMC12784503

Genes

MET
BSG

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